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Rosetta Commons Research Experience for Undergraduates

Interns in this geographically-distributed REU program have the opportunity to participate in research using the Rosetta Commons software. The Rosetta Commons software suite includes algorithms for computational modeling and analysis of protein structures. It has enabled notable scientific advances in computational biology, including de novo protein design, enzyme design, ligand docking, and structure prediction of biological macromolecules and macromolecular complexes.

Students learn the inner details of the Rosetta C++ code and community coding environment. Students research in a molecular modeling and design laboratory, developing new algorithms and discovering new science. Interns are mentored by faculty and graduate interns.

The Program:

-One week of Rosetta Code School, where you will learn the inner details of the Rosetta C++ code and community coding environment, so you are fully prepared for the summer!

-8 weeks of hands-on research in a molecular modeling and design laboratory, developing new algorithms and discovering new science.

 -The summer will finish with a trip to the Rosetta Conference, where you will present your research in a poster and connect with Rosetta developers from around the world. The sponsor, NSF, will provide housing, travel expenses, and a stipend.

Possible projects include:

  • “Design of self-assembling protein nanomaterials: three-dimensional crystals”
  • “Structural bioinformatics of protein kinases”
  • “How do post-translational modifications change the communication of a protein with its partners?”
  • “Glycoengineering for immunotherapy and biofuels”
  • “Rosetta Computer Aided Drug Design”
  • “Computational Redesign of UDP-N-acetylhexosamine pyrophosphorylase for bioorthogonal labeling of protein glycosylation”

…and many more


Desired Skills & Experience: 

-College Sophomores or Juniors preferred.

-Major in computer science, engineering, mathematics, chemistry, biology, and/or biophysics.

-Available for at least 10 weeks during the summer of 2018.

-Interest in graduate school

-While not required, we seek candidates with some combination of experiences in scientific or academic research, C++/Python/*nix/databases, software engineering, object-oriented programming, and/or collaborative development.

-Only U.S. citizens and permanent residents are eligible to apply per NSF guidelines.