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Internship in cutting edge brain tumor and stem cell research

Participate in cutting edge research in the fields of neural stem and progenitor cells with the long-term goal to improve therapies for brain tumor patients. Join the laboratory that discovered asymmetric cell division in the mammalian adult brain and help us to uncover the origin for the myelin sheet and brain tumors.
The Petritsch lab aims to unravel how cell fate decisions are derailed in tumorigenesis and to thereby find novel therapeutic vulnerabilities in gliomas. Oligodendrocyte progenitor cells (OPC) are one potential origin of human oligodendroglioma and astrocytoma. OPC are the only adult brain cell type reported to undergo asymmetric cell divisions (ACD) to determine the fate of their progeny. ACD are a fundamental mechanism to establish cell fate diversity and when disrupted can turn normal oligodendrocyte progenitor cells into tumor cells. To uncover the mechanism for ACD, we use time-lapse imaging, stem cell culturing, cutting-edge molecular and cellular approaches such as Crispr/Cas9 and preclinical tumor models. The applicant will help in the development and enhancement of such approaches.
We provide training for:
- Planning of mouse model experiments and genotyping; mouse handling is optional
- Cell isolation and culturing of primary murine progenitor cells
- Molecular biological and cell culture based assays including quantitative tests for differentiation and polarity/asymmetric cell division, Crispr/Cas9
-time-lapse imaging
 
You will be helping out an experienced student in the lab, attend lab meetings and discussion groups and participate in data generation for manuscripts. The Petritsch lab has a history of mentoring interns to become paid research staff or to enter medical or graduate school, depending on their plans.
Pls include a CV stating your research interest, future career plans, past semester grades (unoffical) and GPA (unofficial). If applicable, pls provide detailed description of prior research experience and list 2-3 references. Pls specify how long you would like to commit for this internship and what your ideal schedule and time commitment would look like.

About Petritsch Laboratory Helen Diller Cancer Center

Cutting-edge research in stem and progenitor cell biology to overcome therapy resistance in brain tumorigenesis
Stem Cell and Cancer Research