Research Scientist | Directed Evolution

M13 Therapeutics is a MIT-founded gene therapy startup developing a next-generation platform

for redoseable in-vivo gene delivery. Our company is harnessing the human phageome to

engineer a diverse set of nanoparticles, called phage-derived particles (PDPs), to deliver

genomic medicines to human cells with high efficiency and specificity.

PDPs are highly engineerable scaffolds capable of multi-functional capsid display of cell

type-specific targeting and endosomal escape moieties. Furthermore, PDPs enable the

packaging of minimal phage DNA (mpDNA) cargos exceeding 20 kb, translating into the ability

to package >99% of human genes as a therapeutic.

Our mission is to treat human diseases and create impactful science in the field of genomic

medicines. We are an early-stage startup where employees will have the advantage of growing

with the company and shaping our culture and vision.

Cambridge, MA

M13 Therapeutics seeks a team-oriented, organized, and creative Research Scientist. As an

early key member of M13 Therapeutics, you will help build our in-vitro and in-vivo directed

evolution platform to identify lead PDPs for efficient and cell type-specific transduction. Your

work will reside at the intersection of computational biology, high-throughput screening, and

disease biology to establish novel workflows to optimize the performance of M13’s PDP capsids

for specific therapeutic indications. The ideal candidate should have experience working in a

fast-paced, collaborative environment to advance their own research goals while also effectively

contributing to matrixed project teams.

● Design, execute, and troubleshoot assays to optimize biological properties of M13 phage

capsids to meet indication-specific performance criteria in close collaboration with

disease biology & platform team

● Conduct high-throughput screens using directed evolution, pooled barcoding methods,

and arrayed screening approaches to optimize the activity of PDP capsids in mammalian

systems

● Establish molecular biology & cloning workflows to generate diverse PDP variant

libraries for high-throughput functional screens

● Provide oversight and mentorship to direct reports

● Analyze data and maintain laboratory notebooks to ensure documentation of

experimental results

● Communicate data and results to research teams and other company forums

● Contribute to building a culture that embraces M13 Therapeutics’ values

● PhD or equivalent in the area of biomedical engineering, synthetic biology, biochemistry,

structural biology, or related bioscience field

● 0-3 years of relevant post-doc work experience; industry experience and experience

managing direct reports strongly preferred

● Hands-on experience in protein engineering and methods for directed evolution in

mammalian cell systems is essential

● In-depth knowledge of molecular biology & library cloning techniques

● Familiarity with standard mammalian cell culture techniques, including methods for gene

delivery

● Detail-oriented with excellent organizational and communication skills

● Must enjoy working in a fast-paced dynamic and highly-collaborative environment

● Excellent collaboration, communication, and interpersonal skills are required to work with

cross-departmental teams/functions to drive discovery projects

● Demonstrated experience in protein purification, biochemical assay development is a

plus

Please forward CV and brief interest paragraph to careers@m13tx.com.